TOFA (RMI14514) | AcetylCoA Carboxylase Inhibitor ...
TOFA (5tetradecyloxy2furoic acid) is cytotoxic to lung cancer cells NCIH460 and colon carcinoma cells HCT8 and HCT15, with an IC 50 at approximately,, and μg/mL, respectively. TOFA at – μg/mL effectively blocks fatty acid synthesis and induces cell death in a dosedependent is found to be cytotoxic to COC1 and COC1/DDP cells with IC 50 values of ~ ...